Figure 4. PKUMDL-YC-1205 blocks the interaction between c-Myc370–409 and Max.
(a) PKUMDL-YC-1205 abolished cMyc370–409 binding to Max in the SPR competitive assay at the indicated concentrations. (b) PKUMDL-YC-1205 disrupted the Max-Max/c-Myc-Max dimerization equilibrium. Chemical cross-linking and anti-Max western blotting results are shown (left). Blackness integrals of the GST-Max homodimer percentage are shown as a histogram (right). Data represent the mean ± standard deviation of two independent experiments. *p < 0.05.