Table A.2.

Association between GC SNPs and other biomarkers adjusted for 25(OH)D and sex

Biomarker	SNP	Coefficient (95% CI)	p-value	Interaction p-value†
Lipid markers
Triglycerides	rs7041	0.02 (−0.05,0.08)	0.58	0.25
	rs2282679	0.02 (−0.05,0.08)	0.55	0.25
LDL	rs7041	−0.02 (−0.06,0.03)	0.43	0.36
	rs2282679	−0.02 (−0.06,0.03)	0.43	0.38
HDL	rs7041	0.00 (−0.04,0.04)	0.84	0.33
	rs2282679	0.00 (−0.04,0.04)	0.92	0.33
Cholesterol	rs7041	0.00 (−0.03,0.03)	0.95	0.10
	rs2282679	0.00 (−0.03,0.03)	0.89	0.10
Cardiovascular disease related markers
Diastolic BP	rs7041	0.00 (−0.01,0.02)	0.78	0.33
	rs2282679	0.00 (−0.02,0.02)	0.75	0.33
Systolic BP	rs7041	0.01 (−0.01,0.02)	0.34	0.79
	rs2282679	0.01 (−0.01,0.02)	0.34	0.79
HbA1c	rs7041	0.00 (−0.01,0.02)	0.76	0.92
	rs2282679	0.00 (−0.01,0.02)	0.76	0.92
IGF-1	rs7041	0.01 (−0.05,0.07)	0.77	0.90
	rs2282679	0.01 (−0.06,0.07)	0.86	0.89
Inflammatory markers
IL-6	rs7041	−0.34 (−0.67,−0.00)	0.05	0.03
	rs2282679	−0.34 (−0.67,−0.00)	0.05	0.03
CRP	rs7041	−0.43 (−1.08,0.22)	0.19	0.39
	rs2282679	−0.43 (−1.08,0.22)	0.19	0.39
Coagulation markers
D-dimer	rs7041	−0.02 (−0.14,0.10)	0.71	0.56
	rs2282679	−0.02 (−0.13,0.10)	0.78	0.57
Fibrogen	rs7041	−0.16 (−0.39, 0.06)	0.16	0.02
	rs2282679	−0.16 (−0.39, 0.06)	0.16	0.02

^†Bonferroni corrected p-value 0.05/11 = 0.004;

- Where the biomarkers have been log transformed to achieve a normal distribution