Table A.2.
Biomarker | SNP | Coefficient (95% CI) | p-value | Interaction p-value† |
---|---|---|---|---|
Lipid markers | ||||
Triglycerides | rs7041 | 0.02 (−0.05,0.08) | 0.58 | 0.25 |
rs2282679 | 0.02 (−0.05,0.08) | 0.55 | 0.25 | |
LDL | rs7041 | −0.02 (−0.06,0.03) | 0.43 | 0.36 |
rs2282679 | −0.02 (−0.06,0.03) | 0.43 | 0.38 | |
HDL | rs7041 | 0.00 (−0.04,0.04) | 0.84 | 0.33 |
rs2282679 | 0.00 (−0.04,0.04) | 0.92 | 0.33 | |
Cholesterol | rs7041 | 0.00 (−0.03,0.03) | 0.95 | 0.10 |
rs2282679 | 0.00 (−0.03,0.03) | 0.89 | 0.10 | |
Cardiovascular disease related markers | ||||
Diastolic BP | rs7041 | 0.00 (−0.01,0.02) | 0.78 | 0.33 |
rs2282679 | 0.00 (−0.02,0.02) | 0.75 | 0.33 | |
Systolic BP | rs7041 | 0.01 (−0.01,0.02) | 0.34 | 0.79 |
rs2282679 | 0.01 (−0.01,0.02) | 0.34 | 0.79 | |
HbA1c | rs7041 | 0.00 (−0.01,0.02) | 0.76 | 0.92 |
rs2282679 | 0.00 (−0.01,0.02) | 0.76 | 0.92 | |
IGF-1 | rs7041 | 0.01 (−0.05,0.07) | 0.77 | 0.90 |
rs2282679 | 0.01 (−0.06,0.07) | 0.86 | 0.89 | |
Inflammatory markers | ||||
IL-6 | rs7041 | −0.34 (−0.67,−0.00) | 0.05 | 0.03 |
rs2282679 | −0.34 (−0.67,−0.00) | 0.05 | 0.03 | |
CRP | rs7041 | −0.43 (−1.08,0.22) | 0.19 | 0.39 |
rs2282679 | −0.43 (−1.08,0.22) | 0.19 | 0.39 | |
Coagulation markers | ||||
D-dimer | rs7041 | −0.02 (−0.14,0.10) | 0.71 | 0.56 |
rs2282679 | −0.02 (−0.13,0.10) | 0.78 | 0.57 | |
Fibrogen | rs7041 | −0.16 (−0.39, 0.06) | 0.16 | 0.02 |
rs2282679 | −0.16 (−0.39, 0.06) | 0.16 | 0.02 |
Bonferroni corrected p-value 0.05/11 = 0.004;
- Where the biomarkers have been log transformed to achieve a normal distribution