Table 3.
Chr | Gene | SNP | bp Location | A1 | N | Unadjusted All | N | Unadjusted | Adj Age | Adj Age, Sex | Adj Age, Sex, BMI | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR | L95 | U95 | P | OR | L95 | U95 | P | OR | L95 | U95 | P | OR | L95 | U95 | P | OR | L95 | U95 | P | |||||||
2 | CAPN10 | rs2975760 | 241531413 | C | 317 | 0.62 | 0.31 | 1.24 | 0.175 | 259 | 0.52 | 0.25 | 1.07 | 0.074 | 0.42 | 0.19 | 0.92 | 0.030 | 0.44 | 0.20 | 0.96 | 0.040 | 0.44 | 0.20 | 0.97 | 0.042 |
2 | CAPN10 | rs5030952 | 241542953 | T | 314 | 0.80 | 0.57 | 1.12 | 0.197 | 257 | 0.78 | 0.54 | 1.15 | 0.208 | 0.82 | 0.55 | 1.21 | 0.314 | 0.80 | 0.54 | 1.20 | 0.280 | 0.80 | 0.54 | 1.19 | 0.274 |
3 | PPARG | rs17036314 | 12376995 | C | 300 | 0.96 | 0.67 | 1.38 | 0.824 | 242 | 1.12 | 0.74 | 1.71 | 0.596 | 1.18 | 0.75 | 1.84 | 0.474 | 1.14 | 0.73 | 1.78 | 0.558 | 1.16 | 0.74 | 1.81 | 0.517 |
3 | IGF2BP2 | rs4402960 | 185511937 | G | 317 | 0.86 | 0.63 | 1.18 | 0.349 | 260 | 0.93 | 0.66 | 1.31 | 0.684 | 0.93 | 0.65 | 1.33 | 0.693 | 0.95 | 0.66 | 1.35 | 0.767 | 0.95 | 0.66 | 1.36 | 0.777 |
3 | IGF2BP2 | rs1470579 | 185529330 | A | 316 | 1.01 | 0.72 | 1.42 | 0.959 | 258 | 1.02 | 0.70 | 1.49 | 0.924 | 0.99 | 0.66 | 1.46 | 0.941 | 1.00 | 0.68 | 1.49 | 0.986 | 1.02 | 0.68 | 1.51 | 0.930 |
6 | CDKAL1 | rs9465871 | 20717505 | C | 315 | 1.27 | 0.94 | 1.73 | 0.120 | 257 | 1.17 | 0.83 | 1.65 | 0.376 | 1.15 | 0.81 | 1.65 | 0.432 | 1.15 | 0.80 | 1.65 | 0.456 | 1.15 | 0.80 | 1.66 | 0.443 |
10 | HHEX | rs1111875 | 94463132 | A | 319 | 0.71 | 0.50 | 1.01 | 0.060 | 261 | 0.68 | 0.45 | 1.02 | 0.060 | 0.61 | 0.40 | 0.94 | 0.026 | 0.61 | 0.40 | 0.95 | 0.027 | 0.60 | 0.39 | 0.93 | 0.022 |
10 | TCF7L2 | rs7903146 | 114758599 | T | 301 | 1.69 | 1.21 | 2.38 | 0.002 | 245 | 1.62 | 1.11 | 2.37 | 0.013 | 1.75 | 1.18 | 2.61 | 0.006 | 1.81 | 1.21 | 2.70 | 0.004 | 1.79 | 1.20 | 2.67 | 0.005 |
10 | TCF7L2 | rs11196205 | 114807297 | G | 306 | 0.78 | 0.58 | 1.06 | 0.117 | 248 | 0.68 | 0.48 | 0.96 | 0.029 | 0.63 | 0.44 | 0.91 | 0.013 | 0.64 | 0.44 | 0.92 | 0.017 | 0.64 | 0.44 | 0.93 | 0.018 |
10 | TCF7L2 | rs12255372 | 114809152 | T | 319 | 1.70 | 1.20 | 2.41 | 0.003 | 261 | 1.53 | 1.04 | 2.25 | 0.031 | 1.57 | 1.06 | 2.33 | 0.026 | 1.58 | 1.07 | 2.35 | 0.023 | 1.60 | 1.08 | 2.38 | 0.021 |
11 | KCNJ11 | rs5215 | 17408880 | C | 315 | 1.13 | 0.69 | 1.85 | 0.622 | 257 | 0.96 | 0.56 | 1.63 | 0.877 | 1.02 | 0.59 | 1.77 | 0.944 | 1.05 | 0.60 | 1.84 | 0.852 | 1.04 | 0.60 | 1.82 | 0.881 |
11 | KCNJ11 | rs5219 | 17409822 | T | 316 | 1.24 | 0.71 | 2.16 | 0.452 | 258 | 1.11 | 0.60 | 2.06 | 0.735 | 1.25 | 0.66 | 2.37 | 0.500 | 1.31 | 0.68 | 2.51 | 0.419 | 1.27 | 0.66 | 2.45 | 0.468 |
Data are presented for an unadjusted analysis for all participants in the study, and for unadjusted and adjusted (as indicated) analyses performed in the subset of individuals for whom complete data on age, sex and BMI was available. Chr = chromosome; bp Location indicates the chromosomal base pair location of the SNP in Genome Reference Consortium Human Build 38 (GRCh38); OR = odds ratio; L95 and U95 indicate lower and upper 95 % confidence intervals. Bold indicates data for SNPs with P<0.05