Table 1.
Genes associated with susceptibility to DENV in humans and mosquitoes
| Host | Gene | Type of variation | Method | Associated with | Reference(s) |
|---|---|---|---|---|---|
| Human | MICB | Genetic | GWAS | Severe dengue | [153] |
| Human | PLCE1 | Genetic | GWAS | Severe dengue | [153] |
| Mosquito | Early trypsin | Genetic | QTL analysis | Midgut infection | [86, 87] |
| Mosquito | Dicer-2 | Genetic | Candidate gene sequencing | GxG interactions | [93] |
| Mosquito | Cecropin | Transcriptomic | Microarray/RNAi | Midgut, salivary gland infection | [66, 70] |
| Mosquito | Defensin | Transcriptomic | Microarray/RNAi | Midgut infection | [70] |
| Mosquito | DVRF1 | Transcriptomic | Microarray/RNAi | Midgut infection | [68] |
| Mosquito | DVRF2 | Transcriptomic | Microarray/RNAi | Midgut infection | [68] |
| Mosquito | Vacuolar ATPase | Transcriptomic | Microarray/RNAi | Midgut infection | [84, 189] |
| Mosquito | High mobility group box protein (HMGB) | Transcriptomic | Microarray/RNAi | Midgut infection | [84] |
| Mosquito | ML33 | Transcriptomic | Microarray/RNAi | Midgut infection | [186] |
| Mosquito | NPC1b | Transcriptomic | Microarray/RNAi | Midgut infection | [186] |
GWAS genome-wide association study, GxG genotype-by-genotype, QTL quantitative trait loci, RNAi RNA interference