Table 4.
Prevalence of HBsAg and BCP/PC mutations observed among HBV genotype A and D sequences
| Mutation (%)a | ||
|---|---|---|
| Nucleotide mutation | Genotype A | Genotype D |
| HBsAg amino acid substitutionsb | 11/77 (14) | 0 |
| BCP/PC insertion/deletionsc | 5/70 (7) | 0 |
| C1653T | 2/70 (3) | 3/9 (33) |
| A1752C | 0 | 1/9 (11) |
| T1753V | 3/70 (4) | 2/9 (22) |
| A1762T/G1764Ad | 23/70 (33) | 4/9 (44) |
| G1809T | 65/70 (93) | 0 |
| A1811T/C | 7/70 (10) | 0 |
| C1812T | 62/70 (89) | 0 |
| C1858T | 4/70 (6) | 9/9 (100) |
| G1862T/C | 24/70 (34) | 0 |
| G1888A | 47/70 (67) | 0 |
| G1896A | 3/70 (4) | 4/9 (44) |
aGenotype A: 77 and 70 samples could be amplified for HBsAg and BCP/PC sequences, respectively; Genotype D: Sequence was available in both regions for all 9 samples. bThe following substitutions within the antigenic determinant region (amino acids 100–160) of the HBsAg gene were observed: M103I, L109P, I110L, G112R, T114S, T115A, T118K, Q129R, G130N, M133I, F134I/V, P135H, T143M, S155R; csee text; dincludes A1762/A1764 (6 genotype A and 2 genotype D) and T1762/G1764 (3 genotype A)