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. Author manuscript; available in PMC: 2016 Dec 18.
Published in final edited form as: ACS Chem Biol. 2015 Oct 28;10(12):2891–2899. doi: 10.1021/acschembio.5b00592

Figure 6.

Figure 6

Dimerization of PPS1 triggers the activity of PPS1. (a) MTS cell viability assay results on HCC4017 with the treatment of PPS1, Cystein-PPS1 and PC462 and Cystein-PPS1 treated on HBEC30KT. Only Cystein-PPS1 treated with HCC4017 displayed cell killing activity. (b) Cartoon depicting the suspected disulfide bond formation between two c-terminal Cysteine labelled PPS1. (c) Structure of PPS1 homo-dimer PPS1D1. (d) Scrambled version of PPS1D1, PC2D1. (e) MTS cell viability assay results on HCC4017 and HBEC30KT treated with PPS1D1, PPS1, PC2D1, PC462D1. Only PPS1D1 treated with HCC4017 displayed cell killing activity.