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Schematization of Lingo-1 actions on APP metabolism in neurons.
Lingo-1 favors both β cleavage by β-secretase and APP lysosomal proteolysis. APP: Amyloid precursor protein; Aβ: amyloid-beta peptides; AICD: APP Intra-Cellular Domain; CTF: carboxy-terminal fragments; Lingo-1: leucine-rich repeat neuronal protein 1; p3: peptide 3; PS-secretase: preselinin-secretase; sAPP: soluble APP.
