Table 5. Longitudinal Association of CAC Score at Baseline (n=1840) with the Presence of Myocardial Scar (n=146) at Year 10.

Models	CAC=0 (n=1043)		CAC 1-99 (n=470)			CAC 100-399 (n=213)			CAC>=400 (n=114)			Log(CAC+1)
	# with scars/ Total*	OR (95% CI)	# with scars/ Total	OR (95% CI)	p	# with scars/ Total	OR (95% CI)	p	# with scars/ Total	OR (95% CI)	p	# with scars/ Total	OR (95% CI)	p
Model 1	37/1043	1 (ref)	50/470	2.4 (1.5,3.9)	<0.001	34/213	3.0 (1.7,5.1)	<0.001	25/114	3.3 (1.7,6.1)	<0.001	146/1840	1.2 (1.1,1.3)	<0.001
Model 2	36/1010	1 (ref)	47/460	2.2 (1.4,3.5)	0.001	34/209	2.6 (1.5,4.6)	0.001	24/112	3.1 (1.6,5.9)	0.001	141/1791	1.2 (1.1,1.3)	<0.001
Model 3	35/1000	1 (ref)	47/451	2.2 (1.3,3.6)	0.002	34/207	2.5 (1.4,4.5)	0.001	24/109	3.2 (1.6,6.2)	0.001	140/1767	1.2 (1.1,1.3)	<0.001
Model 4	24/766	1 (ref)	35/335	2.3 (1.3,4.1)	0.004	23/156	2.2 (1.1,4.3)	0.029	16/82	2.2 (1.0,4.8)	0.05	98/1339	1.1 (1.0,1.3)	0.009

All covariates taken from baseline (Exam 1).

^*Numerators and denominators include only those subjects who have all observed variables.

Log (CAC+1): CAC was log-transformed after adding 1 (due to values of 0 CAC score) for the continuous models.

Model 1: adjusted for age, gender and race/ ethnicity;

Model 2: variables in Model 1 plus systolic blood pressure, hypertension medication, total cholesterol, HDL cholesterol, lipid medication, smoking status, diabetes, GFR, household income>$50k;

Model 3: variables in Model 2 plus BMI, LV mass, LV end-diastolic volume, LV ejection fraction;

Model 4: variables in model 3 plus average of left and right distal mean common carotid artery intimal media thickness