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. 2016 Feb 1;3(3):166–179. doi: 10.1002/acn3.293

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Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Clinical scores showed tendency for worsening during the observation period for both treated and placebo groups. (A) Clinical scores of expanded disability status scale (EDSS), Scripps neurological rating scale (NRS), and multiple sclerosis functional composite (MSFC) for patients in active treatment and placebo cohorts. (B) Average cumulative contrast‐enhancing lesion (CEL) counts on brain MRI for patients in active treatment and placebo cohorts.