. 2015 Aug 25;3(1):10–16. doi: 10.1093/nop/npv026

Table 2.

Odds ratios of glioma for confirmed genetic inherited variants

Risk Variant Location		Odds Ratio^a
Chromosome	Nearby Gene	Odds Ratio^a
All glioma types^b
3	TERC	1.2
5	TERT	1.3
7	EGFR	1.2
8	CCDC26^c	1.4
9	CDKN2B/ANRIL	1.3
11	PHLDB1	1.2
17	TP53	2.4
20	RTEL1	1.2
Oligodendroglial and IDH-mutated astrocytic tumors
8	CCDC26^d	6.3

^aOdds ratios are for number of risk alleles. The source of the odds ratios are the following references: TERC [reference #10]; TERT, EGFR, CCDC26 (for all gliomas), CDKN2B/ANRIL, PHLDB1, RTEL1 [reference #6]; TP53 [reference #3]; CCDC26 for oligodendroglial and IDH-mutated astrocytic tumors [reference #19].

^bIncludes WHO grades II-IV astrocytoma, oligodendroglioma, oligoastrocytoma.

^cvariant is rs4295627.

^dvariant is rs55705857.

Abbreviations: TERC, telomerase RNA component; TERT, telomerase reverse transcriptase; EGFR, epidermal growth factor receptor; CCDC26, coiled-coil domain-containing protein 26; CDKN2B, cyclin-dependent kinase inhibitor 2B/ANRIL, antisense noncoding RNA in the INK4 locus; PHLDB1, pleckstrin homology-like domain, family B, member 1; TP53, tumor protein P53; RTEL1, regulator of telomere elongation helicase 1.