Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jan 13;11(3):695–702. doi: 10.3892/etm.2016.2993

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Suchorska et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 1. — (A) Response of undifferentiated and differentiated cells to genotoxic agents differs, because of distinct cell cycle and cell metabolism. (B) Mammalian cells are exposed to the influence of DNA damage (single- or double-strand breaks) agents. In DNA repair mechanisms, base excision repair, nucleotide excision repair (NER), mismatch repair, homologous recombination and non-homologous end joining are involved many genes. (C) Failure of DNA repair may direct the cells to apoptosis or to differentiation. ESCs, embryonic stem cells; ROS, reactive oxygen species; GG-NER, global genome-NER; TC-NER, transcription-coupled NER.