Table II.
Effects of BBR on arrhythmia in IRI model rats.
| PVC | VT | VF | ||||||
|---|---|---|---|---|---|---|---|---|
| Group | Number | Incidence | Count | Incidence | Duration (sec) | Incidence | Duration (sec) | VA score |
| Sham | 10 | 50 | 9±11 | 0 | 0 | 0 | 0 | 0.4±0.5 |
| IRI | 10 | 80 | 37±22a | 60 | 27.2±24.6a | 40 | 15.5±17.2a | 5.0±4.3a |
| BBR (25 mg/kg) | 10 | 80 | 32±21b | 50 | 22.7±26.6b | 40 | 11.5±14.7b | 4.2±4.1b |
| BBR (50 mg/kg) | 10 | 60 | 21±15b | 30 | 10.8±16.6b | 15 | 5.6±7.8b | 2.5±3.2b |
| BBR (100 mg/kg) | 10 | 60 | 15±12b | 20 | 3.4±7.0b | 5 | 1.8±4.2b | 1.5±3.0b |
Results were obtained by the analysis of electrocardiograms. BBR, berberine; IRI, ischemia/reperfusion injury; PVC, pre-ventricular contraction; VF, ventricular fibrillation; VT, ventricular tachycardia; VA, ventricular arrhythmia. Values are presented as the mean ± standard deviation.
a
P<0.05 vs. the sham group.
b
P<0.05 vs. the IRI group.