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Effect of the cisplatin and MK-2206 combination in the gastric cancer cell lines, AGS, MGC-803 and MKN-45. Following treatment with cisplatin for 24 h, followed with MK-2206 for another 48 h, the results of the MTT assay showed that MK-2206 can significantly increase the effect of cisplatin in AGS cells (P<0.05), but MK-2206 showed a slight combination effect in the other two cell lines.
