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Effect of cisplatin and MK-2206 combination on the expression of total Akt, p-Akt and cleaved poly adenosine diphosphate ribose polymerase (PARP). MK2206 can significantly inhibit the expression of p-Akt (Ser473), and there was no difference in the level of total Akt in these four groups. In the combination group, the level of cleaved PARP was higher compared to the other three groups. DMSO, dimethyl sulfoxide.
