Table I.

Clinicopathological features of tongue squamous cell carcinoma patients and their association with α-SMA and CD19 expression in the tumor microenvironment.

	Patients		Collagen fiber content		α-SMA		CD19
Characteristics	n	%	Mean ± SD	P-value	Mean rank	P-value	Mean rank	P-value
Age, years				0.334		0.813		0.609
<50	42	45.2	0.10±0.09		47.70		44.51
≥50	51	54.8	0.12±0.10		46.42		47.22
Gender				0.215		0.047		0.687
Male	56	60.2	0.13±0.11		51.35		45.12
Female	37	39.8	0.10±0.09		40.42		47.28
Clinical stage				0.239		0.374		0.912
I–II	51	54.8	0.10±0.09		43.44		44.25
III–IV	42	45.2	0.13±0.10		48.19		44.83
Tumor stage				0.031		0.001		0.479
1–2	78	85.7	0.10±0.10		42.34		44.27
3–4	13	14.3	0.17±0.09		67.69		49.69
Node stage				0.966		0.209		0.207
0	63	69.2	0.11±0.11		48.23		47.22
1–3	28	30.8	0.11±0.10		40.98		40.16
Pathological differentiation				0.231		0.125		0.217
Well-differentiated	47	50.5	0.10±0.09		39.80		44.64
Moderately differentiated	40	43.0	0.14±0.11		52.84		46.56
Poorly differentiated	6	6.5	0.10±0.10		44.00		26.50
Overall survival				0.865		0.361		0.011
Alive	39	41.9	0.12±0.11		30.86		35.95
Succumbed to disease	25	26.9	0.11±0.09		35.06		24.46
Missing	29	31.2	0.11±0.11

Collagen fiber content is expressed as a ratio of the percentage of collagen fiber content in the tumor stroma. SMA, smooth muscle actin; CD, cluster of differentiation; SD, standard deviation; Mean rank, the mean as determined by the rank sum test.