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Mammalian rhomboid family proteins
| Rhomboids | Number of TM domains | Catalase activity | Localization |
|---|---|---|---|
| PARL | 7 | Yes | Mitochondrial inner membrane |
| RHBDL1 | 7 | Yes (predicted) | Golgi |
| RHBDL2 | 7 | Yes | Plasma membrane |
| RHBDL3 | 7 | Yes (predicted) | Endosomes |
| RHBDL4 (RHBDD1) | 6 | Yes | ER |
| iRhom1 | 7 | No | ER-Golgi |
| iRhom2 | 7 | No | ER-Golgi |
| Derlin1 | 6 | No | ER |
| Derlin2 | 6 | No | ER |
| Derlin3 | 6 | No | ER |
| UBAC2 | 6 | No | ER |
| TMEM115 | 6 | No | ? |
| RHBDD2 | 6 | No | Golgi |
| RHBDD3 | 6 | No | ? |
Reference: Bergbold and Lemberg et al., 2013.
