Table 1. Sex differences in intrapulmonary NA metabolism are not caused by mEH KO.

We measured statistically higher metabolism in control male intrapulmonary airways for most endpoints (p < 0.05). Data are expressed as the mean ± SD for n =5-6 as nmoles metabolite/mg protein/120 minutes.

	Wildtype			Knockout
	Male	Female	P-value	Male	Female	P-value
Conjugate 1	8.10 ± 3.38	6.30 ± 3.02	NS	15.2 ± 7.91	3.70 ± 1.83	0.006
Conjugate 2	293 ± 99.2	162 ± 66.3	0.022	267 ± 69.2	114 ± 41.7	0.001
Conjugate 3	11.3 ± 4.50	5.69 ± 3.04	0.028	19.1 ± 7.72	3.49 ± 0.690	0.002
Conjugate 4	18.2 ± 8.43	5.47 ±2.33	0.019	16.7 ± 4.79	4.20 ± 0.830	< 0.001
Dihydrodiol	113 ± 43.5	60.4 ± 14.9	0.025	2.43 ± 0.890	2.04 ± 0.580	NS
Total	443 ± 156	239 ± 87.5	0.023	320 ± 70.0	130 ± 51.2	< 0.001