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. 2016 Jan 26;11(3):1829–1834. doi: 10.3892/ol.2016.4142

Figure 2.

Figure 2.

The association between Tim-3 expression on CD4+ and CD8+ T cells in TILs and the clinicalpathological characteristics of patients. (A and B) Association between Tim-3 expression and the World Health Organisation grade of glioma, as calculated by Mann-Whitney U test, on (A) CD8+ (glioma grade II–III, 7.391±0.727, n=22; and glioma grade IV, 15.72±0.9835, n=31) and (B) CD4+ T cells (glioma grade II–III, 10.29±0.9405, n=22; and glioma grade IV, 19.76±1.117, n=31). (C and D) Correlation between Tim-3 expression and the KPS score of patients, as calculated by Spearman's correlation analysis, on (C) CD8+ and (D) CD4+ T cells. Significance was indicated by P-values, ***P<0.001. Each symbol represents a single individual. Data are expressed as the mean ± standard error of the mean. CD, cluster of differentiation; Tim-3, T cell immunoglobulin- and mucin-domain-containing molecule 3; TILs, tumor-infiltrating lymphocytes; KPS, Karnofsky Performance Status.