Table IV.

Correlation between changes in sputum ET-1 level and changes in TTP in patients receiving anti-tuberculosis chemotherapy.

Day	Correlation coefficient (r)	P-value
1	−0.52	<0.01
2	−0.42	<0.01
4	−0.43	<0.01
6	−0.46	<0.01
10	−0.49	<0.01
14	−0.56	<0.01

Patients with active pulmonary TB were treated with a weight-adjusted fixed-dose of Rifafour e-275. Changes in the sputum ET-1 level (pg/ml) and in TTP from baseline (day 0) on days 1, 2, 4, 6, 10 and 14 were expressed as ΔSputum ET-1 and ΔTTP, respectively. Spearman rank tests were performed to analyze the correlation between ΔSputum ET-1 and ΔTTP at each time point. ET, endothelin; TTP, time to positivity.