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. 2016 Jan 29;11(3):2207–2212. doi: 10.3892/ol.2016.4162

Figure 3.

Figure 3.

Overexpression of miR-497 inhibited the cell migration and invasion abilities of human osteosarcoma MG63 cells. (A) The number of migrated MG63 cells was determined using a Transwell® assay without Matrigel™ 24 h subsequent to transfection with miR-497 mimic or miR-control. (B) The number of invaded MG63 cells was determined using a Transwell® assay with Matrigel™ 48 h subsequent to transfection with miR-497 mimic or miR-control. (C) Western blot analysis of uPA, MMP-2 and MMP-9 protein expression following transfection with miR-497 mimic or miR-control. GAPDH was used as an internal control. *P<0.05, **P<0.01 vs. miR-control. miR, microRNA; MMP, matrix metalloproteinase; uPA, urokinase plasminogen activator; GAPDH, glyceraldehyde-3-phosphate dehydrogenase.