Figure 4.

miR-497 inhibits tumor growth in vivo. (A) Representative image of tumors formed in BALB/c xenograft mouse models at 28 days following injection with human osteosarcoma MG63 cells transfected with a miR-497 mimic or miR-control. (B) Growth curve of tumors volume measured at the indicated times. (C) Weight of xenograft tumors. (D) Reverse transcription-quantitative polymerase chain reaction analysis of the expression levels of miR-497 in tumor tissues of miR-497 mimic and miR-control groups. *P<0.05, **P<0.01 vs. miR-control. miR, microRNA.