Table II.
Targets of metastasis associated lung adenocarcinoma transcript 1 in cancer.
| Cellular system | Modulators | Target molecules | Biological consequences | References |
|---|---|---|---|---|
| HeLa cells | p53 | Cell cycle arrest | (30) | |
| HeLa cells | SRSF1 | Alternative splicing | (28) | |
| Human cervical cancer | Caspase-3, caspase-8, Bax, Bcl-2 and Bcl-xL | Cell growth, cell cycle progression and invasion | (44) | |
| Gallbladder carcinoma | ERK/MAPK | Proliferation and metastasis | (17) | |
| Gallbladder carcinoma | Cyclin D1, cyclin E and CDK6 | Cell migration and proliferation | (49) | |
| Bladder cancer | TGF-β | Epithelial-mesenchymal transition and tumor metastasis | (15) | |
| Bladder cancer | Wnt/β-catenin | Epithelial-mesenchymal transition and sequent cell migration | (16) | |
| Human osteosarcoma | Myc-6 | Cell growth | (48) | |
| Myeloma | Sp1, LTBP3 and TGF-β | Therapeutic target biomarker | (49) | |
| Gastric cancer | SF2/ASF | Cell proliferation | (22) | |
| Colorectal cancer | SFPQ | Tumor metastasis, prognosis and therapeutic target | (54) | |
| Esophageal squamous cell carcinoma | SOX17 | Cell growth and migration | (55) | |
| Liver cancer | YAP, SRSF1 | Transwell mobility | (19) | |
| Neuroblastoma | CREB | Tumor marker | (39) | |
| Human and mouse lung cancer | ASOs | (38) |
SRSF1, serine/arginine-rich splicing factor 1; Bax, Bcl-2-like protein 4; Bcl-2, B-cell lymphoma 2; Bcl-xL, B-cell lymphoma-extra large; TGF-β, transforming growth factor; YAP, yes-associated protein; CREB, cAMP response element-binding protein; ASO, anti-streptolysin O; p53, tumor protein p53; ERK/MAPK, extracellular signal-regulated kinase/mitogen-activated protein kinase pathway; CDK6, cyclin-dependent kinase 6; Sp1, transcription factor Sp1; LTBP3, latent transforming growth factor β binding protein 3; SF2/ASF, splicing factor 2/alternative splicing factor; SFPQ, splicing factor proline/glutamine rich.