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DNMT1 messenger RNA expression in normal breast specimens and breast cancer specimens. 1, normal breast specimens; 2, ERα-positive breast cancer specimens and 3, ERα-negative breast cancer specimens. (β-actin, 301 bp; DNMT1, 152 bp). The ERα-negative breast cancer group (n=36) exhibited the highest expression rate of DNMT1, when compared with the normal breast tissue (n=20) and ERα-positive breast cancer (n=76) groups. *P<0.0001. ER, estrogen receptor; DNMT, DNA methyltransferase.
