Table I.
Characteristics of 16 MM patients with bortezomib-induced severe pulmonary complications.
| First author, year | Age, years | Gender | MM type | Previous history of lung injury | Status of MM prior to bortezomib therapy | Prior transplantation | Ref. |
|---|---|---|---|---|---|---|---|
| Miyakoshi et al, 2006 | 47 | F | IgG | Invasive pulmonary aspergillosis | Relapse | Auto-PBSCT | (6) |
| 59 | F | IgA | Pulmonary embolism | Relapse | Auto-PBSCT | ||
| 48 | F | IgD | No | Relapse | Unrelated bone marrow transplantation | ||
| 53 | F | Unknown | No | Relapse | Auto-PBSCT | ||
| Boyer et al, 2006 | 66 | M | Unknown | No | Relapse | No | (8) |
| Zappasodi et al, 2007 | 66 | M | Unknown | COPD | Refractory | Unknown | (9) |
| Dun et al, 2010 | 72 | M | IgG | No | Relapse | Unknown | (10) |
| 51 | M | IgD | No | Refractory | Unknown | ||
| 72 | F | IgG | No | New | No | ||
| 68 | F | IgG | No | Relapse | Unknown | ||
| 72 | M | IgG | No | Relapse | Unknown | ||
| Kang et al, 2010 | 67 | M | IgG | Unknown | New | No | (11) |
| Yamaguchi et al, 2012 | 64 | M | IgG | No | Relapse | Auto-PBSCT | (12) |
| Vandeix et al, 2012 | 74 | M | IgC | No | New | No | (13) |
| Chew et al, 2007 | 66 | M | IgG | Unknown | New | Auto-PBSCT | (14) |
| Pitini et al, 2007 | 51 | M | IgG | No | Relapse | Auto-PBSCT | (15) |
Ig, immunoglobulin; COPD, chronic obstructive pulmonary disease; auto-PBSCT, autologous peripheral blood stem cell transplantation; M, male; F, female; MM, multiple myeloma.