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. 2016 Feb 1;35(4):1933–1940. doi: 10.3892/or.2016.4602

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Copyright: © He et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of TRAF6 knockdown on the apoptosis of SPC-A1 cells. In the FSC/SSC scattergrams, cancer cells were gated, and the percentage of Annexin V-positive cells in this group of gated cells was determined. PI-negativity indicates early apoptosis, and PI-positivity indicates late apoptosis. (A) Non-transfected group; (B) control siRNA group; (C) TRAF6 siRNA group; (D) percentage of apoptotic cells. siRNA-induced knockdown of TRAF6 resulted in an ~1.5-fold increase in the apoptosis of SPC-A1 cells. These data were analyzed by one-way ANOVA. All experiments were repeated in triplicate. ^**P<0.05 vs. non-transfected or control siRNA.