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. 2016 Jan 13;35(4):1941–1949. doi: 10.3892/or.2016.4554

Figure 5.

Figure 5

Effects of emodin and 5-Aza-CdR on the mRNA expression of P16, RASSF1A, ppENK, DNMT1 and DNMT3a in the PANC-1 cells. (A) FQ-PCR analysis showed that emodin or 5-Aza-CdR alone or in combination increased the mRNA expression levels of P16, RASSF1A and ppENK. (B) FQ-PCR analysis showed that emodin or 5-Aza-CdR alone or in combination decreased the mRNA expression levels of DNMT1 and DNMT3a. *P<0.05, **P<0.01 vs. control or cells treated with 5-Aza-CdR alone. 0, the control group; E, 40 µM emodin group; A, 1 µM 5-Aza-CdR group; E+A, combination group.