Figure 2.
Three-dimensional structure of the antiparallel JIP3-LZII_3-10 fragment. (a) Scheme of the quaternary organization of the antiparallel JIP3-LZII_3-10 homodimer. The primary sequence of JIP3-LZII_3-10 is reported above. (b) Three-dimensional structure of the antiparallel JIP3-LZII_3-10 fragment (two orthogonal views). Leucine residues at position d are indicated in red in (a) and are shown as sticks in (b). Heptad repeats are highlighted using a rainbow colour code. (c) A simulated-annealing composite OMIT map contoured at 1σ is shown for a region overlapping three heptad repeats of the antiparallel JIP3-LZII_3-10 homodimer structure. The simulated-annealing composite OMIT map was calculated on the entire homodimer using PHENIX (Adams et al., 2010 ▸).