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. 2016 Mar 2;11(3):e0149996. doi: 10.1371/journal.pone.0149996

Table 1. P. falciparum protein kinases selected for biochemical high-throughput screening.

Target name (abbreviation) PlasmoDB ID (old ID) Key evidence for importance
Calcium-Dependent Protein Kinase 1 (CDPK1) PF3D7_0217500 (PFB0815w) Essentiality in erythrocyte stages of the life cycle has been validated genetically and chemically [16,9].
Calcium-Dependent Protein Kinase 4 (CDPK4) PF3D7_0717500 (PF07_0072) CDPK4 is essential in gametocytes, though not in erythrocyte stages [17,9,10].
Mitogen-Associated Protein Kinase 2 (MAPK2) PF3D7_1113900 (PF11_0147) MAPK2 is essential in erythrocyte stages (in P. falciparum, though not P. berghei) and in male gametogenesis [1820].
Protein Kinase 6 (PK6) PF3D7_1337100 (MAL13P1.185) PK6 is essential in erythrocyte stages [9,10].
Protein Kinase 7 (PK7) PF3D7_0213400 (PFB0605w) PK7 knockouts fail to complete oocyst development [21]. They also grow slowly in erythrocyte stages, though PK7 is not essential in these stages [9,10].