Calcium-Dependent Protein Kinase 1 (CDPK1) |
PF3D7_0217500 (PFB0815w) |
Essentiality in erythrocyte stages of the life cycle has been validated genetically and chemically [16,9]. |
Calcium-Dependent Protein Kinase 4 (CDPK4) |
PF3D7_0717500 (PF07_0072) |
CDPK4 is essential in gametocytes, though not in erythrocyte stages [17,9,10]. |
Mitogen-Associated Protein Kinase 2 (MAPK2) |
PF3D7_1113900 (PF11_0147) |
MAPK2 is essential in erythrocyte stages (in P. falciparum, though not P. berghei) and in male gametogenesis [18–20]. |
Protein Kinase 6 (PK6) |
PF3D7_1337100 (MAL13P1.185) |
PK6 is essential in erythrocyte stages [9,10]. |
Protein Kinase 7 (PK7) |
PF3D7_0213400 (PFB0605w) |
PK7 knockouts fail to complete oocyst development [21]. They also grow slowly in erythrocyte stages, though PK7 is not essential in these stages [9,10]. |