Table 3. Summary of kinobead competition assays (results reflect two independent experiments).
Compound | Inhibition of HepG2 cell growth at 10 μM [3] | Human kinases quantified on kinobeads (N = 2) | Human kinases with apparent pKd ≥ 4.7 (N = 2) | Human kinases with apparent pKd ≥ 6 (N = 2) |
---|---|---|---|---|
TCMDC-125885 | 33% | 153 | 5 | 1 |
TCMDC-134116 | 43% | 136 | 126 | 96 |
TCMDC-141154 | 48% | 146 | 47 | 26 |
TCMDC-141399 | 47% | 147 | 63 | 24 |