TABLE IV -. Baseline and follow-up (pre- and post-RAN) P&S measures and LVEF in 46^† ranchf patients with and without events. See text for details.

	Pts w/Events+ (N = 15)		Pts w/o Events (N = 31)
	Pre- & Post-RAN	P (LVEF)	Pre- & Post-RAN	P (Bx)
bpm2 = beats per min2; ∆ = change; EFU = ejection fraction unit; E/I ratio = exhalation to inhalation ratio (unitless); HRV = heart rate variability; LFa = low-frequency area (bpm2, a measure of sympathetic activity; see Methods); LVEF = left ventricular ejection fraction; RAN = Ranolazine: RANCHF = congestive heart failure patients treated with RAN; RFa = respiratory frequency area (bpm2, a measure of parasympathetic activity; see Methods); SB = sympathovagal balance (=LFa/RFa, unitless); VR = Valsalva ratio (unitless); 30:15 ratio = ratio of 30th to the 15th R-R interval immediately after standing (unitless); p-value (LVEF) = significance based on correlation with ∆LVEF; p-value (Bx) = significance based on baseline (Bx) measure.
† = 8 RANCHF and 6 NORANCHF patients omitted from analysis due to high-quality arrhythmia preventing HRV-alone analysis.
+ = an event (VT/VF arrhythmia, CHF admission, or death; see Methods).
‡ = an average of ratios, not a ratio of averages (see Methods).
Rest
LFa	2.26 & 0.74	<0.001	1.87 & 1.05	0.011
RFa	1.04 & 0.19	<0.001	0.88 & 1.06	0.006
SB‡	6.18 & 3.04	<0.001	1.26 & 1.08	0.025
Deep breathing
RFa	19.1 & 18.6	<0.001	6.57 & 14.0	0.011
E/I ratio	1.21 & 1.08	<0.636	1.08 & 1.10	0.321
Valsalva challenge
LFa	39.7 & 21.0	<0.001	19.4 & 21.8	0.065
VR	1.55 & 1.28	<0.693	1.26 & 1.22	0.480
Head-up postural change challenge (Stand)
LFa	0.83 & 1.81	<0.001	1.08 & 2.57	0.012
RFa	0.53 & 0.82	<0.001	0.86 & 3.01	0.045
30:15 ratio	1.15 & 1.23	0.120	1.12 & 1.12	0.329
∆LVEF	0.30 to 0.36 (+6 EFUs)	0.018	0.35 to 0.44 (+6 EFUs)	0.005