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. 2016 Mar 2;11(3):e0148110. doi: 10.1371/journal.pone.0148110

Fig 1. Ischemia depresses the amplitude of evoked synaptic transmission without changes in the presynaptic volley amplitude.

Fig 1

(A). fEPSPs were recorded from the stratum radiatum in the CA1 region while the Schaffer collaterals were stimulated every 15 s. fEPEP amplitude decreased reversibly in a time-dependent manner after 2 min (n = 7), 4 min (n = 5), and 6 min (n = 5) of OGD. (B) fEPSP amplitudes produced by 2 min, 4 min, 6 min of in vitro ischemia relative to controls. (C) Fiber volley amplitude after 8 min of OGD (n = 6, p>0.05) Average plotted as mean ± SE. * p < 0.001: paired student t-test. OGD: Oxygen-glucose deprivation, fEPSP: field excitatory postsynaptic potentials.