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. Author manuscript; available in PMC: 2016 Mar 2.
Published in final edited form as: ACS Chem Neurosci. 2015 Dec 7;7(2):240–258. doi: 10.1021/acschemneuro.5b00286

Figure 3.

Figure 3

Compounds 12a, 23d, and 30a selectively inhibit HDAC6 in N2a cells. (A and B) Incubation of N2a cells with 1 μM or 10 nM of the HDAC6 inhibitors results in an increased acetylation of α-tubulin. (C and D) WBs were quantified by measuring the ratio of acetylated α-tubulin to the total amount of α-tubulin. The values were normalized to tubastatin A (TubaA) within each experiment. Graphs represent means with SEM. Dunnett’s multiple comparison test. *p < 0.05, **p < 0.001, ***p < 0.0001. N = 4.