Video 2. Response of wild type and G12V Ras systems in high-GAP network context.

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DOI: 10.7554/eLife.12435.010

The effector output (red) from a representative bead loaded with wild-type Ras (blue) or G12V Ras (green) is shown. 2 μM RasGRF was provided as an activating input and the system contained 1 μM NF1-GAP. Time-steps are separated by 15 min. Associated with data in main-text Figure 3C.

DOI: http://dx.doi.org/10.7554/eLife.12435.010