Figure 1.

Hippo-PCC connectivity significantly predicted episodic memory performance in an independent sample previously published by our laboratory (Wang et al. 2010a). In that study, a contrast comparing high confidence hits vs. fixation identified clusters containing hippocampi activation peaks (left, top) and a contrast comparing fixation vs. high confidence hits identified clusters containing PPC deactivations (left, bottom). Wang et al. (2010a) then used these task-based ROIs as seed ROIs in a subsequent resting state functional connectivity analysis. The strength of intrinsic connectivity between the right hippocampal ROI and right PPC ROI (scatter plot on the right) predicted overall memory performance in their sample of older adults. Figure adapted from Wang et al. 2010a.