Fig. 1.

Physical characterization of L-BPD (red) and L-IRI (blue). (A) Absorption spectra of L-BPD and L-IRI in DMSO. Arrow indicates light excitation wavelength. (B, C) Long-term stability of L-BPD and L-IRI stored in dark conditions (4°C) determined by size and polydispersity. (D) L-BPD and L-IRI exhibit differential drug release profiles under biologically relevant conditions (37°C, 10% serum) (E) Plasma pharmacokinetics of L-BPD (0.25mg/kg) and L-IRI (20mg/kg) in athymic nu/nu mice. (F) Tissue biodistribution of L-BPD (0.25mg/kg) and L-IRI (20mg/kg) in tumor-bearing mice at 1-hour post-IV injection. Extracts from tissue homogenates were analyzed by LC-MS/MS. (N≥3)