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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Structure. 2016 Jan 28;24(3):353–363. doi: 10.1016/j.str.2015.11.016

Figure 5. Binding cooperativity between ATP-competitive inhibitors and pseudo-substrate.

Figure 5

A) ITC isotherms for PKI5-24 binding to PKA-C saturated with Balanol (left), and H89 (right). B) Plot of the Kd of PKI5-24 to PKA-C in the presence and absence of ATP-competitive inhibitors. C) Structure of PKA-C with balanol (PDB:1BX6, orange) and H89 (PDB: 1YDT, blue) with key electrostatic interactions (see also Figure S4–6 and Table S1–2).