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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Structure. 2016 Jan 28;24(3):353–363. doi: 10.1016/j.str.2015.11.016

Figure 6. Chemical Shift Trajectories with Nucleotides and ATP-competitive inhibitors.

Figure 6

A) [1H,15N]-TROSY-HSQC spectra showing the backbone amide chemical shift changes of PKA-C saturated with different ATP-competitive inhibits and nucleotides upon binding PKI5-24. B) Linear correlation between PC1 score and degree of cooperativity of the aggregate chemical shifts including the ATP-competitive inhibitors (see also Figure S7).