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A) [1H,15N]-TROSY-HSQC spectra of the backbone chemical shifts of active site residues in PKA-C. In the ATPγN bound state, many of these resonances experience exchange so they are unobservable (dotted circle). B) Significant chemical shift changes upon binding of balanol and H89. Note that balanol induces more significant chemical shift changes in the active site compared to H89 (see also Figure S7).
