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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Dev Comp Immunol. 2015 Nov 11;58:30–39. doi: 10.1016/j.dci.2015.11.003

Figure 2. B cell development stages in rabbit BM.

Figure 2

Several B lineage progenitors are identified in rabbit BM. The earliest B lineage progenitor identified in the B cell development scheme is the rLP, which expresses Tdt, EBF, and Pax5. Next is the pro-B cell with successful DJ gene rearrangements in the IgH locus, and the pre-B cell with successful VDJ gene rearrangements. Finally, IgM+ B cells develop. HSC- hematopoietic stem cell, Tdt- terminal deoxynucleotidyl transferase, EBF- early B cell factor, Pax5- paired box protein 5, Cμ - cytoplasmic IgM, Sμ - surface IgM