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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Dev Comp Immunol. 2015 Nov 11;58:30–39. doi: 10.1016/j.dci.2015.11.003

Figure 3. Proposed mechanisms that contribute to the arrest of B cell development.

Figure 3

BM from young rabbits is populated by osteoblasts which support B cell development. At this age, osteoblasts, pro-B cells, and pre-B cells are found at their highest numbers in rabbit BM. By 2 months of age these populations are greatly decreased. The BM microenvironment is the major contributor to the loss of B lymphopoiesis, which appears to be blocked at the rLP→pro-B cell stage. In >2 month old rabbits, the BM is filled with adipocytes. We hypothesize that adipocytes produce adipokines and DAMPs which lead to the accumulation of MDSCs which produce IL-1. We further hypothesize that IL-1 acts on rLPs, or yet to-be-defined MPPs, promoting myelopoiesis at the expense of B lymphopoiesis.