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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Clin Cancer Res. 2015 Oct 12;22(5):1211–1221. doi: 10.1158/1078-0432.CCR-15-0663

Figure 5. Sorafenib enhances ATRA-induced apoptosis in HL-60, ME-1 and THP-1 cells and this effect is linked with repression of both Bcl-2 and Mcl-1 proteins.

Figure 5

Sorafenib blocked ATRA-induced Mcl-1, p-p90RSK, p-GSK3β, and p-MEK and enhanced ATRA-induced apoptosis in HL-60 (A, B), ME-1(C, D) and THP-1(E, F) cells. HL-60, ME-1 and THP-1 cells were treated with 1μM ATRA plus 2.5 or 5 μM Sorafenib for 2 days. The levels of the indicated proteins were determined using Western blot analysis (A,C,E) and the apoptotic cells were determined using FACS after staining with Annexin V (B, D, F).