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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Dec 13;1859(3):496–509. doi: 10.1016/j.bbagrm.2015.12.002

Fig. 3. The expression patterns of histone H1 variants during gametogenesis.

Fig. 3

During spermatogenesis, male germ cells undergo unique chromatin remodeling. Somatic H1s were detected in spermatogonia, predominated by H1a and H1c, whose levels steadily decrease in meiotic spermatocytes until their disappearance in round spermatids [126, 133]. H1t is expressed in pachytene spermatocytes and persists until round spermatids [127–130]. The expression of H1T2 and HILS1 is confined to spermatids, with H1T2 in the nuclei of early spermatids and HILS1 in both early and elongated spermatids [26–29]. Similar to spermatogonia, oogonia express a complement of somatic H1s. During oogenesis, somatic H1s are gradually replaced by the oocyte-specific H1oo [24, 101]. However, H10 is retained throughout oogenesis [100–102].