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. Author manuscript; available in PMC: 2017 Mar 14.
Published in final edited form as: Vaccine. 2016 Feb 10;34(12):1452–1458. doi: 10.1016/j.vaccine.2016.01.064

Figure 3.

Figure 3

Neutralizing antibody production following intranasal immunization with GelVac™ vaccine powder. Female Hartley guinea pigs were immunized intranasally with 20 mg of powder formulation containing various amounts of VLP on days 0 and 21. Serum samples were collected on days 0, 14, 21, 42, and 56 and analyzed for GI (A) and GII.4 (B) neutralizing antibodies. Error bars are provided as geometric standard error. *P<0.05 as compared to the placebo control group. Exact adjusted p-values following Dunnett’s multiple comparison test following two-way ANOVA is shown in Supplementary Tables 2C–D.