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. Author manuscript; available in PMC: 2017 Mar 14.
Published in final edited form as: Vaccine. 2016 Feb 10;34(12):1452–1458. doi: 10.1016/j.vaccine.2016.01.064

Figure 4.

Figure 4

Vaginal Norovirus-specific IgG production following intranasal immunization with GelVac™ vaccine powder. Female Hartley guinea pigs were immunized intranasally with 20 mg of powder formulation containing various amounts of VLP on days 0 and 21. Vaginal lavages samples were collected on days 0, 14, 21, 42, and 56 and analyzed for GI (A) and GII.4 (B) Norovirus-specific IgG antibodies. Error bars are provided as geometric standard error. *P<0.05 as compared to the placebo control group. Exact adjusted p-values following Dunnett’s multiple comparison test following two-way ANOVA is shown in Supplementary Tables 2E–F.