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. Author manuscript; available in PMC: 2017 Feb 28.
Published in final edited form as: Thromb Haemost. 2015 Oct 15;115(3):551–561. doi: 10.1160/TH15-07-0525

Figure 1. Cooperative effects of rhFVIIa and superFVa on thrombin generation in FVIII-deficient plasma.

Figure 1

Thrombin generation was determined as ETP (top panel) and thrombin peak height (bottom panel) in FVIIIdP supplemented with (A) either increasing concentrations of superFVa in the absence (open circles) or presence (solid circles) of rhFVIIa (0.4 nM), or (B) increasing concentrations of rhFVIIa in the absence (open circles) or presence (solid circles) of superFVa (3.3 nM). Normalization of thrombin generation is indicated by the reconstitution of FVIIIdP with 2 U/ml FVIII (open squares). ETP denotes Endogenous Thrombin Potential; FVIIIdP, FVIII-deficient plasma. Error bars indicate SEM (n≥5).