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. Author manuscript; available in PMC: 2017 Feb 28.
Published in final edited form as: Thromb Haemost. 2015 Oct 15;115(3):551–561. doi: 10.1160/TH15-07-0525

Figure 2. Cooperative effects of rhFVIIa and superFVa on thrombin generation in normal human plasma containing an anti-FVIII antibody.

Figure 2

Thrombin generation was determined as ETP (top panel) and thrombin peak height (bottom panel) in NHP supplemented with 1.25 µg/ml anti-human FVIII-antibody (40 BU). Increasing concentrations of either (A) superFVa in the absence (open circles) or presence (closed circles) of rhFVIIa (0.4 nM), or (B) increasing concentrations of rhFVIIa in the absence (open circles) or presence (closed circles) of a fixed concentration of superFVa (3.3 nM) were used. Thrombin generation in NHP in the absence of the inhibitory anti-FVIII antibody is indicated by the open squares. ETP denotes Endogenous Thrombin Potential; NHP, normal human plasma. Error bars represent standard error of the mean (n≥5).