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. Author manuscript; available in PMC: 2017 Feb 28.
Published in final edited form as: Thromb Haemost. 2015 Oct 15;115(3):551–561. doi: 10.1160/TH15-07-0525

Figure 3. Cooperative effects of rhFVIIa and superFVa on thrombin generation in plasma from patients with congenital FVIII-deficiency and high titer anti-FVIII antibodies.

Figure 3

Thrombin generation was determined as ETP (top panel) and peak height (bottom panel) in (A) plasma samples with inhibitors from two patients seen at the University of California San Diego Hemophilia Treatment Center or (B) commercial plasma samples with inhibitors from three different patients. ETP was determined at two different concentrations of superFVa or rhFVIIa, or combinations thereof. Inhibitor titers are expressed in BU. Pooled NHP served as control. ETP denotes Endogenous Thrombin Potential; NHP, normal human plasma; BU, Bethesda Unit. Error bars represent standard error of the mean (n≥3).