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. Author manuscript; available in PMC: 2017 Feb 28.
Published in final edited form as: Thromb Haemost. 2015 Oct 15;115(3):551–561. doi: 10.1160/TH15-07-0525

Figure 4. Cooperative effects of superFVa on thrombin generation in plasma of two patients with congenital FVIII-deficiency and high titer anti-FVIII antibodies treated with rhFVIIa during acute bleeding episodes.

Figure 4

Plasma samples were obtained just before (open circles) and 5 min post infusion of rhFVIIa at 90 µg/kg (open squares) from two patients with BU-titers of 64 U/mL (Patient A) and 32 U/ml (Patient F). Thrombin generation was determined as ETP (top panel) or peak height (bottom panel) with increasing concentrations of superFVa added to plasma samples ex vivo. ETP denotes Endogenous Thrombin Potential; BU, Bethesda Unit. Error bars represent standard error of the mean (n≥3).