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. Author manuscript; available in PMC: 2017 Feb 28.
Published in final edited form as: Thromb Haemost. 2015 Oct 15;115(3):551–561. doi: 10.1160/TH15-07-0525

Figure 7. Bleed correction with superFVa, rhFVIIa, mFVIIa and combinations thereof in BalbC mice injected with an inhibitory anti-FVIII antibody.

Figure 7

BalbC mice were injected intravenously with an inhibitory antibody against FVIII (0.25 mg/kg) resulting in an inhibitor titer of 35 BU. Bleeding was determined for 20 min after tail clip and expressed in Tl blood loss per gram mouse. (A) Blood loss was measured by intravenous injection of saline, increasing doses of superFVa or rhFVIIa and a combination of rhFVIIa and superFVa at low concentrations. (B) Blood loss was measured by intravenous injection of increasing doses of mFVIIa and a combination of mFVIIa and superFVa at low concentrations. Error bars represent mean ± SEM (n = 8). 1 Unit superFVa = activity of 20 nM wild-type FVa in the prothrombinase assay. * p≤ 0.05; ** p≤ 0.005; *** p≤ 0.0005; NS, not significant.